Electrospinning of in situ synthesized silica-based and calcium phosphate bioceramics for applications in bone tissue engineering: A review

The field of bone tissue engineering (BTE) focuses on the repair defects that are too large to be restored by natural healing process. To purpose, synthetic materials mimicking extracellular matrix (ECM) widely studied and many combinations compositions architectures possible. In particular, electrospinning process can reproduce fibrillar structure ECM stretching a viscoelastic solution under an electrical field. With this method, nano/micrometer-sized fibres produced, with adjustable chemical composition. Therefore, shaping bioactive ceramics such as silica, glasses calcium phosphates through electrospinning, promising properties for their use in BTE obtained. This review situ synthesis simultaneous bioceramic-based while reasons using each material correlated its bioactivity. Theoretical practical considerations these developed. Finally, investigations into vitro vivo bioactivity different systems inorganic exposed.